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In turn, phosphorylation of the adaptor proteins insulin receptor substrate 14 (IRS-14) and Shc leads to activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways (Baserga, 2000)

And so at the end of the day, you're going to get a disappointing answer, but I'm not really sure Now

Notes: Risk of hypoglycaemia/hypokalaemia continuous monitoring